June 3-5, 2008
Millennium Harvest House Boulder
Boulder, Colorado
Consortium Program and Research Activities
Tuesday, June 3, 2008
5:00pm - 6:00pm Reception (No Host Bar); Location: Firepit Room
6:00pm - 6:15pm Steve Cummings: Opening Remarks & Introduction Of Participants
6:15pm - 7:00pm Dinner; Location: Flagstaf Room
7:15pm - 8:00pm Mario Fraga: Epigenetic mechanisms in aging and cancer
8:00pm - 8:30pm Group Discussion
Wendesday, June 4, 2008 Canyon Half of BallRoom
7:30am - 8:30am Breakfast
SESSION ONE: GENETICS ON HUMAN LONGEVITY I - PROGRESS REPORTS OF SOF PROJECTS AWARDEES
8:30am - 8:45am Gil Atzmon: Whole genome association analysis in DNA pools to discover genes for exceptional longevity
8:45am - 9:00am Bradley Willcox: Genetic basis Of exceptional longevity in Okinawa
STUDY
SESSION TWO: GENETICS ON HUMAN LONGEVITY II - DEEP SEQUENCING THE HUMAN GENOME; NEW PROJECT IDEAS, COHORT FOR ANALYSIS AND INITIAL FINDINGS
9:00am - 9:20am Greg Tranah: Identifying rare variants in the extremes of adult lifespan
9:20am - 9:40am Kelly Frazer: Sequencing of ‘longevity genes’ in members of the ‘wellderly cohort’
9:40am - 10:00am Thomas Perls: Recent genetic findings from the New England and Southern Italian Centenarian studies
10:00am - 10:20am COffee Break
10:20am - 10:40am Eline Slagboom: Status of gwas analysis in longitudinal studies of aging
10:40am - 11:00am Elad Ziv: Insulin/igf-1 signaling pathway genes and human longevity
11:00am - 11:20am Wen-Chi Hseuh: Gwas of variants in micrornas and their relationship to human longevity: design of a high-throughput sequencing method
SESSION THREE: GENETICS ON HUMAN LONGEVITY II - DEEP SEQUENCING THE HUMAN GENOME; METHODS AND ANALYSIS
11:20am - 11:40am Ludmila Pawlikowska: Genomics and genotyping methods core
11:40am - 12:00pm Nicholas Schork & Caroline Nievergelt: Biostatistics and bioinformatics core
12:00am - 12:20pm Alex reiner: analytic approaches to multivariate phenotypes
SESSION FOUR: PROTEIN HOMEOSTASIS IN THE AGING PROCESS
2:00pm - 2:30pm Matt Kaeberlein (U. Washington) – Modulation of longevity and proteotoxicity by altered mrna translation
2:30pm - 3:00pm Tali Gidalevitz (Northwestern U.) -Disturbance of protein folding homeostasis in aging and in models of aging-related diseases
3:00pm - 3:30pm Ana Maria Cuervo (Albert Einstein) – Autophagy and aging
3:30pm - 3:45pm Coffee Break
SESSION FIVE: SHORT PRESENTATIONS
3:45pm - 4:00pm Abraham Aviv: Leukocyte telomere dynamics and the biology of successful aging and longevity in humans
SESSION ENDS
4:00pm - 5:30pm Meeting of CHARGE Aging Working Group and Invited Guests
Thursday, June 5, 2008 Canyon Half of BallRoom
7:30am - 8:20am Breakfast
8:20am - 8:50am Joanne Murabito: Report On the activities Of The Charge Aging Working Group
SESSION SEVEN: CONSORTIUM AND SOF* PROGRESS REPORTS AND NEW PROPOSALS USING ANIMAL MODELS
8:50am - 9:10am Andrzej Bartke and Michal Masternak: Search for candidate longevity genes in mutant mice
9:10am - 9:30am Richard Miller: Stress resistance, aging rates, and lifespan
9:30am - 9:45am Thomas Johnson & Wallace Chick: Generation of oxidative resistant mutant mice
9:45am - 10:00am Gordon Lithgow and Silvestre Alavez: Molecular chaperones as determinants of human longevity
10:00am - 10:20am Coffee Break
SESSION EIGHT: ANIMALS AND IN VITRO MODELS FOR ASSESSING THE FUNCTION OF SPECIFIC ALLELES AND GENETIC PATHWAYS IN AGING AND LONGEVITY
10:20am - 10:40am Gordon Lithgow: Functional genomics core
Opportunity Fund Proposals
10:40am - 11:00am Yair Argon: Grp94 variants and insulin/igf signaling
Longevity Consortium Investigator Proposal
11:00am - 11:20am Richard Miller: Longevity-limiting cellular processes inferred from comparative biology
Presentations Conclude: Meeting Officially Ends
12:00pm - 2:00pm Executive Session: Administrative Core, NIA Representatives, and Others