November 17-19, 2010
Hilton New Orleans St. Charles Avenue Hotel
New Orleans, LA
Pathways and Mechanisms in Physiological Aging and Age-related Disease
Wednesday, November 17, 2010
6:00 PM - 6:45 PM Poster-Reception (Cash Bar)
6:45 PM - 7:00 PM Steve Cummings (San Francisco Coordinating Center): Opening Remarks and Introduction of Participants
7:00 PM - 7:45 PM Banquet Dinner
7:45 PM - 8:30 PM Plenary Presentation - Leanne Jones (Salk Institute, La Jolla, CA): Aging-related changes to stem cells and the stem cell niche
Thursday, November 18, 2010
7:00 AM - 8:00 AM Breakfast
SESSION ONE: MECHANISMS OF FUNCTIONAL DECLINE IN THE AGING AND DEMENTIA-EFFECTED BRAIN
8:00 AM - 8:30 AM Jonathan Kipnis (U. Virginia, Charlottesville, VA): Immune function in learning,memory and aging
8:30 AM - 9:00 AM Amy Sanders (Albert Einstein School of Medicine, NY, NY) Cognitive Longevity: Longevity-Associated Benefits in Cognitive Aging
9:00 AM - 9:30 AM Dimitri Avramopoulos (McKusick Nathan Institute of Genetic Medicine, Baltimore) The importance of gene regulation in age-related disease and healthy aging in the brain
9:30 AM - 10:00 AM Giovanni Coppola (UCLA, Los Angeles): Genetic and genomic analysis of dementia and aging
10:00 AM - 10:15 AM Coffee Break
SESSION TWO: BASIC MECHANISMS IN THE CONTROL OF AGING
10:15 AM - 10:30 AM Punkaj Kapahi (Buck Institute for Age Research, Novato, CA): Is mTOR a central mediator in aging and longevity?
10:50 AM - 11:10 AM Ergun Sahin (Dana Farber Cancer Institute, Boston, MA): Telomere dysfunction is associated with PGC repression and mitochondrial/metabolic changes in multiple tissues
11:10 AM - 11:40 AM Greg Tranah (California Pacific Medical Center, San Francisco, CA): Mitochondrial gene variation and longevity
SESSION THREE: PHYSIOLOGICAL AGING AND CHRONIC AGE-RELATED DISEASE
ARTICULAR CARTILAGE (OSTEOARTHRITIS)
11:40 AM - 12:10 PM Richard Loeser (Wake Forest University, Winston-Salem, NC): Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the artilage matrix.
12:10 PM - 12:40 PM Martin Lotz (Scripps Institute, La Jolla, CA): Mesenchymal progenitor cells in normal and osteoarthritic cartilage
12:40 PM - 3:30 PM Lunch (on your on) and Afternoon Break
3:30 PM - 4:30 PM Poster Session and Wine and Cheese Reception
SESSION FOUR: PHYSIOLOGICAL AGING AND CHRONIC AGE-RELATED DISEASE (con’t)
THE AGING EYE
4:30 PM - 5:00 PM Cynthia Owsley (U. Alabama, Birmingham): Age-related vision impairment and its impact on the quality of life
5:00 PM - 5:30 PM Christine Curcio (U Alabama, Birmingham): Aging, age-related macular degeneration and lipoproteins: the ‘oil spill’ in Bruch's membrane
5:30 PM - 6:00 PM Cynthia T. McMurray (Lawrence Berkeley National Lab): Death by DNA Repair: The Role of Oxidative DNA Damage in Age-Dependent Neurodegeneration
LINKING PHYSIOLOGICAL AGING TO AGE-RELATED DISEASE: THE BEGINNINGS OF A DISCUSSION
5:30 PM - 6:30 PM Steve Cummings (California Pacific Medical Center, San Francisco): Moderator
MEETING ADJOURNS FOR DAY
Dinner (on your own)
Friday, November 19, 2010
7:00 AM - 8:00 AM Breakfast
SESSION FIVE: PHYSIOLOGICAL AGING AND CHRONIC AGE-RELATED DISEASE (con’t)
The Aging SKIN
8:00 AM - 8:30 AM Gary Fisher (U Michigan, Ann Arbor): Oxidative stress and matrix metalloproteinases in aging skin
8:30 AM - 9:00 AM Thea Mauro (UCSF, San Francisco): Changing barrier function in aging human skin
SESSION SIX: INFLAMMATION, AGING AND CHRONIC AGE-RELATED DISEASE INCLUDING CVD
9:00 AM - 9:30 AM Judith Campisi (Buck Institute for Age Research): The DNA damage response links inflammation, tumor suppression and aging
9:30 AM - 10:00 AM Jeremy Walston (Johns Hopkins U, Baltimore, MD) - Inflammation and frailty in the elderly: findings from human subjects and a mouse model
10:00 AM - 10:20 AM Coffee Break
THE AGING CARDIOVASCULR SYSTEM (Cardiovascular Disease)
10:20 AM - 10:50 AM Russell Tracy (U. Vermont, Burlington, VT): The inflammation hypothesis of aging -the role of cardiovascular disease
10:50 AM - 11:20 AM Lewis Kuller (U Pittsburgh, Pittsburgh, PA): High prevalence of vascular disease in the elderly and the resulting increase in clinical disease
11:20 AM - 11:50 AM Jay Eldelberg (Bristol-Myers-Squibb): Stem cells for cardiovascular repair – the challenges of the aging heart
LINKING PHYSIOLOGICAL AGING TO AGE-RELATED DISEASE: CONTINUING THE DIALOGUE
11:50 AM - 12:30 PM Warren Browner (California Pacific Medical Center, San Francisco): Moderator